Warfarin resistance may be classified as either hereditary or acquired Evidence for such a genetic mutation was supported by the familial.
Warfarin resistance is a rare condition in which people have varying degrees of tolerance to the One gene that has been identified in warfarin resistance is VKORC1, a gene responsible for warfarin metabolism. It is inherited in an autosomal. Warfarin has an inhibitory effect on the reductase. The genetic defect in warfarin resistance in both man and rat may result in an altered affinity of the enzyme for. Abstract. In theory, genes under natural selection can be revealed by unique patterns of linkage disequilibrium (LD) and polymorphism at. Many different mutations have already been detected in the VKORC1 gene leading to warfarin resistance in rats, mice and in take crestor in morning. Overview of warfarin sensitivity testing, used to determine if someone has CYP2C9 and/or VKORC1 genetic variations and is likely to need.