Amiodarone and hyperthyroidism


Amiodarone can lead to both hypothyroidism (amiodarone-induced hypothyroidism) and less commonly hyperthyroidism (amiodarone-induced thyrotoxicosis).

Amiodarone induced hyperthyroidism. FREE subscriptions for doctors and students. click here. You have 3 open access pages. Amiodarone-induced thyrotoxicosis (AIT) develops in 3% of Amiodarone and its metabolites demonstrate direct toxicity to cultured thyroid cells exposed to. Amiodarone is a potent antiarrhythmic drug that is used to treat ventricular and supraventricular tachyarrhythmias Thyroid abnormalities have been noted in up to 14-18% of patients receiving long-term amiodarone therapy The effects range from abnormal thyroid function test.

Amiodarone is a benzofuranic-derivative iodine-rich drug widely used for the In 14-18% of amiodarone-treated patients, there is overt thyroid dysfunction. This is a condition called type I amiodarone induced thyrotoxicosis (hyperthyroidism). In addition, it can also cause type II amiodarone induced thyrotoxicosis. The effects of amiodarone on thyroid does tylenol work with alcohol can be divided into those effects that are intrinsic properties of the drug, and those effects that are due to iodine.

It may be challenging to distinguish the thyroid effects of amiodarone because these may present as a change in frequency or severity of arrhythmias for which. Amiodarone bears a remarkable structural resemblance to thyroid hormones. The free base contains 39% iodine by weight (fig 1), and chronic treatment is.

For an overview of amiodarone and thyroid function, see Effects of amiodarone therapy on thyroid function Nat Rev Endocrinol. 2010 Jan;6(1):34-41 and. Amiodarone treatment results in a large iodine load and affects thyroid status by decreasing peripheral deiodination of thyroxine (T4) to.